Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

POMGNT2

contributors: mct - updated : 15-10-2012

HGNC name	protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
HGNC id	25902

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	26.84 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032806 2 - 2556 NP_116195 66.5 580 - 2012 22958903

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Nervous brain forebrain cerebral cortex   predominantly Homo sapiens   brain hindbrain cerebellum   predominantly Homo sapiens Urinary kidney       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac   highly Homo sapiens Muscular striatum skeletal   highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	highly expressed during brain and eye development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a fibronectin III domain that is not essential for the enzymatic activity of POMGNT2

HOMOLOGY

intraspecies

homolog to highly homologous to EOGT

Homologene

FAMILY

glycosyltransferase 61 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	glycosyltransferase activity
	might encode O-GlcNAc transferase that specifically glycosylates DAG1
	POMGNT2-dependent modification sites are mainly distributed in the O-mannosylated region and not limited to the LARGE-targeting sequence
	novel glycosyltransferase catalyzing GlcNAcylation in the ER

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	is a novel glycosyltransferase catalyzing GlcNAcylation of O-mannosylated DAG1 in the ER
	modifies O-mannose on the mucin-like domain of DAG1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

WLKWS6

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS