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FLASH GENE
Symbol APRG1 contributors: SGE/npt - updated : 03-12-2009
HGNC name chromosome 3 open reading frame 35
HGNC id 24082
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal part conserved among members of the eukaryotic translation factor 6 gene family
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a tumor suppressor gene (Leris 2005)
  • implicated in cell membrane interactions (Leris 2005)
  • may be directly involved in membrane interactions and cell adhesion (Protopopov 2003)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer (expression negatively correlated with progressive disease: alive with metastasis, local recurrence, died of breast cancer, all progressive disease)
    tumoral     --low  
    frequently and extensively methylated in renal carcinoma cell lines
    tumoral   deletion    
    in renal, lung and breast carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS