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FLASH GENE
Symbol APRG1 contributors: SGE/npt - updated : 03-12-2009
HGNC name chromosome 3 open reading frame 35
HGNC id 24082
Location 3p22.2      Physical location : -
Genatlas name AP20 region protein 1
Synonym name Alu-PCR clone 20 region protein
Synonym symbol(s) C3orf35
DNA
TYPE functioning gene
STRUCTURE 36.02 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D3S4495 - D3S3623 - APRG1 - D3S4038 - D3S3452 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1558 18.4 170 pancreas, placenta Protopopov (2003), Leris (2005)
  • isoform B
    • 5 - 1807 13.04 119 - Protopopov (2003), Leris (2005)
  • isoform E
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Respiratoryrespiratory tracttrachea   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal part conserved among members of the eukaryotic translation factor 6 gene family
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a tumor suppressor gene (Leris 2005)
  • implicated in cell membrane interactions (Leris 2005)
  • may be directly involved in membrane interactions and cell adhesion (Protopopov 2003)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a tumour suppressor gene (Leris 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer (expression negatively correlated with progressive disease: alive with metastasis, local recurrence, died of breast cancer, all progressive disease)
    tumoral     --low  
    frequently and extensively methylated in renal carcinoma cell lines
    tumoral   deletion    
    in renal, lung and breast carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS