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FLASH GENE
Symbol GUF1 contributors: mct - updated : 17-11-2016
HGNC name GUF1 GTPase homolog (S. cerevisiae)
HGNC id 25799
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated Other
HOMOLOGY
interspecies homolog to rattus Guf1 (88.8 pc)
homolog to murine Guf1 (89.9 pc)
Homologene
FAMILY
  • GTP-binding elongation factor family
  • LepA subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    text
  • is located in the mitochondrial matrix and tightly associated with the inner membrane
    • basic FUNCTION
  • being a small GTPase mediated signal transduction
  • probable function of GUF1 as a fidelity factor of mitochondrial protein synthesis
  • triggers back-translocation of the elongating ribosome, causing the translation machinery to move one codon backwards along the mRNA
  • it plays a critical role under suboptimal translation conditions
  • protein essential in conditions that counteract faithful protein synthesis: it is able to remobilize stuck ribosomes and transiently inhibit the elongation process to optimize protein synthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
  • binds to mitochondrial ribosomes in a GTP-dependent manner
    • cell & other
    REGULATION
    Other ubiquitinated
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE40
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS