Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

FDX1L

contributors: mct - updated : 20-11-2017

HGNC name	ferredoxin 1-like
HGNC id	30546

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.2      Physical location : 10.420.890 - 10.426.691
Synonym name	adrenodoxin-like protein, mitochondrial
	ferredoxin-1-like protein
Synonym symbol(s)	MGC19604, MGC74760, FDX2

DNA

TYPE	functioning gene
STRUCTURE	5.80 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001031734 5 - 852 NP_001026904 19.4 183 - 2012 22101253

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       moderately Reproductive male system prostate     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	predominantly in umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a 2Fe-2S ferredoxin-type domain

HOMOLOGY

interspecies	ortholog to functional orthologue of yeast Yah1
	homolog to rattus Fdx1l (85.1 pc)
	homolog to murine Fdx1l (83.9 pc)

Homologene

FAMILY

adrenodoxin/putidaredoxin family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
text	present in the matrix of human mitochondria

basic FUNCTION	involved in electron transport chain
	essential for Fe/S protein biogenesis in human cells and can functionally replace FDX1 (Sheftel 2010)
	unlike FDX1, is unable to reduce mitochondrial cytochrome P450 (Sheftel 2010)
	involved in heme A formation and Fe/S protein biogenesis, and is also essential for the maturation of cytosolic Fe/S proteins, underscoring the importance of mitochondria in all Fe/S protein production in the eukaryotic cell (Sheftel 2010)
	is the second component of the Fe-S cluster biogenesis machinery, the first being ISCU that is associated with isolated mitochondrial myopathy
	FDX1L, FDX1, play an important role as an electron donor in iron-sulfur (Fe-S) cluster biosynthesis
	FDX1L, FDX1 can function in Fe-S cluster assembly

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

signaling

a component

essential component of the Fe/S protein biogenesis pathway (Sheftel 2010)

INTERACTION

DNA

RNA

small molecule	cofactor,
	binding to a 2Fe-2S cluster

protein

interference with any of the three related genes, FDX1, FDX1L or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS