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FLASH GENE
Symbol FCRLB contributors: npt/KTN - updated : 10/12/2008
HGNC name Fc receptor-like B
HGNC id 26431
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 17 aa hydrophobic leader peptide
  • two or three Ig-like C2-type (immunoglobulin-like) domains
  • a C-terminal domain enriched in proline, serine, and threonine
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to chimpanzee FCRLB (99.5 pc)
    homolog to cow FCRLB (88.5 pc)
    homolog to rattus Fcrlb (86.2 pc)
    homolog to murine Fcrlb (83.6 pc)
    Homologene
    FAMILY
  • immunoglobulin family
  • Fc receptor family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may play a role in regulating clonal expansion or differentiation of B cells during the germinal center reaction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    may be up-regulated in the progression of melanocytic tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS