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FLASH GENE

Symbol

FCRLB

contributors: npt/KTN - updated : 10/12/2008

HGNC name	Fc receptor-like B
HGNC id	26431

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.48 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	Chikaev et al. (2005) cloned several FCRL2 splice variants

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed FCRLB 6 - 1794 46.8 426 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       moderately Lymphoid/Immune lymph node       highly Reproductive female system breast mammary gland   highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 17 aa hydrophobic leader peptide
	two or three Ig-like C2-type (immunoglobulin-like) domains
	a C-terminal domain enriched in proline, serine, and threonine

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to chimpanzee FCRLB (99.5 pc)
	homolog to cow FCRLB (88.5 pc)
	homolog to rattus Fcrlb (86.2 pc)
	homolog to murine Fcrlb (83.6 pc)

Homologene

FAMILY	immunoglobulin family
	Fc receptor family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION

may play a role in regulating clonal expansion or differentiation of B cells during the germinal center reaction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   may be up-regulated in the progression of melanocytic tumors

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS