basic FUNCTION
| is a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response |
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recruited to sites of stalled replication via ubiquitinated PCNA and plays an important role to prevent mutations associated with replication of damaged DNA |
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recruited to sites of replication stress, a process that depends on its PCNA- and ubiquitin-interacting domains and the RAD18 PCNA ubiquitin ligase |
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cell cycle-regulated anaphase-promoting complex (APC) substrate that accumulates at stalled replication forks |
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is a DNA damage-targeting VCP adaptor that protects cells from deleterious consequences of replication blocks |
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is a regulator of cellular responses to DNA damage that prevents mutations when DNA damage occurs |
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negatively regulates error-prone translesion synthesis (TLS) that is dependent on POLD3, the accessory subunit of the replicative DNA polymerase Pol delta |
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having a function in translesional DNA synthesis and the prevention of mutagenesis |
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essential role for SPRTN in the prevention of DNA replication stress during general DNA replication and in replication-related G2/M-checkpoint regulation |
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plays a key role in maintaining structural and numerical chromosome integrity |
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is a mammalian protease required for resolving DNA-protein crosslinks |
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SPRTN accomplishes DPC processing through a unique DNA-induced protease activity, which is controlled by several sophisticated regulatory mechanisms |
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is a specialized DNA-dependent and DNA replication-coupled metalloprotease for DNA-protein crosslinks (DPCs) repair |
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represents a specialized DNA replication-coupled DPC repair pathway essential for DNA replication progression and genome stability |
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nuclear metalloprotease that is involved in the repair of DNA-protein crosslinks |