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FLASH GENE
Symbol CRYBB2 contributors: shn/npt - updated : 22-05-2012
HGNC name crystallin, beta B2
HGNC id 2398
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • an ABAB pattern structural motif, characteristic of the beta-gamma crystallin superfamily
  • four beta/gamma crystallin 'greek key' domains linked by a connecting peptide and N- and C-terminal extensions
  • 16 beta-strands, 8 in the N-terminal domain and 8 in the C-terminal domain
    • conjugated Other
    mono polymer homomer , heteromer , dimer , oligo
    HOMOLOGY
    interspecies ortholog to crybb2, Danio rerio
    ortholog to Crybb2, Mus musculus
    ortholog to crybb2, Danio rerio
    Homologene
    FAMILY
  • beta/gamma-crystallin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • contributing to the refractive index and transparency of lens
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text cell shape and cell size control
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    photoreception
    a component
  • homo/heterodimer or complexes of higher order
  • the structure of beta-crystallin oligomers sems to be stabilized through interactions between the N-terminal arms
  • being the dominant structural component of the vertebrate eye lens
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alphaA-, and alphaB- crystallins, and Hsp27 (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CCA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • decreased levels of Camk4 in the testis is a contributing factor to reduced fertility in male Crybb2-/- mice (