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FLASH GENE
Symbol EYS contributors: mct/npt/shn - updated : 24/10/2010
HGNC name eyes shut homolog (Drosophila)
HGNC id 21555
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twenty-eight EGF-like domains
  • five laminin A G-like domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to eys, Drosophila melanogaster
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • being essential for photoreceptor morphology
  • might be sequestered in the extracellular matrix, also known as the subretinal space, between the (developing) photoreceptors and RPE
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • interaction with PROM1 (could be involved in ROS disc morphogenesis)
  • might interact directly or indirectly with the extracellular domain of CRB1 or its homolog CRB2 and in this way form a critical component of Müller cell–photoreceptor cell and photoreceptor cell–photoreceptor cell interactions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RP25
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS