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FLASH GENE
Symbol EDC3 contributors: mct - updated : 24-10-2016
HGNC name enhancer of mRNA decapping 3 homolog (S. cerevisiae)
HGNC id 26114
Corresponding disease
MRT50 mental retardation, autosomal recessive 50
Location 15q24.1      Physical location : 74.922.899 - 74.988.386
Synonym name
  • yjeF domain containing (E.coli)
  • LSM16 homolog (EDC3, S. cerevisiae)
  • enhancer of mRNA decapping 3
  • LSM16 homolog
  • Synonym symbol(s) YJDC, LSM16, YJEFN2, FLJ21128, FLJ31777, hYjeF_N2-15q23
    DNA
    TYPE functioning gene
    STRUCTURE 65.49 kb     10 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4086 55.9 508 -
    8 - 3871 55.9 509 - -
    7 - 3781 55.9 508 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegranulosa cell
    ReproductiveSertoli cell
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal Lsm domain
  • a central FDF domain
  • a C-terminal YjeF N-terminal domain
  • HOMOLOGY
    interspecies homolog to murine Edc3 (95.7 pc)
    Homologene
    FAMILY
  • YjeF_N family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • may play a role in mRNA decapping
  • may play a role in spermiogenesis and oogenesis
  • having similar functions in oogenesis and sperm maturation which is strengthened by the identification of the spermatogenesis regulator HMGA1 as a conserved transcription factor
  • implicated in cholesterol processing and steroid hormone metabolism in spermiogenesis and oogenesis
  • enhancer of decapping and serves as a scaffold that aggregates mRNA ribonucleoproteins together for P-body formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • spermiogenesis
  • oogenesis
  • PATHWAY
    metabolism nucleic
    signaling
    mRNA degradation
    a component
  • forming a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS
  • dimeric form of EDC3 is a structural and functional unit in mRNA degradation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacting with DCP1A and DDX6
  • interacting with ZFP36
  • interacting with DDX6 (DDX6 C-terminal RecA-like domain bound to a highly conserved FDF sequence motif in the decapping activator EDC3)
  • EDC3 binding to DCP2 is mediated by a short peptide sequence located C terminal to the catalytic domain of DCP2
  • PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3
  • DDX6 interacts with the CNOT1 complex and functions in concert with several post-transcriptional regulators, including EDC3, and EIF4ENIF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRT50
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS