Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FN1 contributors: mct/npt - updated : 09-01-2018
HGNC name fibronectin 1
HGNC id 3778
ASSOCIATED DISORDERS
corresponding disease(s) EDS10 , GFND2 , SMDCF1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in prostate cancer cells
tumoral       gain of function
up-regulated in germ cells yolk sac tumors
tumoral     --over  
in renal cancer
Susceptibility susceptibility to lung fibrosing alveolitis in systemic sclerosis
Variant & Polymorphism
Candidate gene
  • EPPIN-FN1 complex may involve in semen coagulation, liquefaction and the survival and preparation of spermatozoa for fertility in the female reproductive tract
    • Marker
  • FN1 mRNA expression might serve as a marker for renal cell cancer (RCC) aggressiveness, indicating early systemic progression particularly for patients with papillary RCC
  • serum- and CSF-FN1 levels constitute a potential clinical diagnostic biomarker for epilepsy and could also be used for differential diagnosis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    offers crucial molecular insights and promises to develop putative candidate therapeutic interventions in women with ovarian cancer
    ANIMAL & CELL MODELS