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FLASH GENE
Symbol FN1 contributors: mct/npt - updated : 09-01-2018
HGNC name fibronectin 1
HGNC id 3778
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • P2 adhesive glycoprotein
  • 12 fibronectin type-I domains
  • two fibronectin type-II domains
  • 16 fibronectin type-III domains, and he third type III domain (3FN3) interacts with other parts of fibronectin and with anastellin, a protein fragment that causes fibronectin aggregation
  • a gelatin-binding domain (GBD)
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text extracellular matrix
    basic FUNCTION
  • involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape
  • it might be a critical molecule produced by T(H)1 cells involved in pathogen eradication
  • upregulates osteoclast activity despite inhibiting osteoclast formation and these effects involve nitric oxide and IL1B signaling
  • laminin and fibronectin may play crucial roles in the control of trophoblast adhesion and invasion, in placentation and angiogenesis
  • glycoprotein involved in cellular adhesion and migration processes
  • O-glycosylated oncofetal fibronectin has a synergistic effect with transforming growth factor (TGFB1) in EMT induction
  • FN1 and WNT7A together regulate the homeostatic levels of satellite stem cells and satellite myogenic cells during regenerative myogenesis
  • is a key factor in serum to recruit mesenchymal progenitor cells and might be involved in subchondral mesenchymal progenitor cell migration into cartilage defects after microfracture
  • is essential for endogenous cardiac progenitor cells (CPCs) expansion and repair required for stabilization of cardiac function after myocardial infarction (MI)
  • FN1 and ITGA5 play requisite roles in cardiac morphogenesis
  • EPPIN and FN1 bind to each other in human semen and on human ejaculated spermatozoa
  • opposing effects of collagen I and VTN on FN1 fibril structure and function
  • FN1 matrix plays a crucial role in the regulation of angiogenesis during development, tissue repair and pathogene
  • is an ECM glycoprotein substantially expressed during tissue repair
  • indispensable role for FN1 in chronic liver fibrosis/cirrhosis in negatively regulating TGFB1 bioavailability, which in turn modulates ECM remodeling and stiffening and consequently preserves adult organ functions
  • Dental Bud Stem Cells (DBSCs) differentiation toward osteoblastic lineage was enhanced when cells were grown on fibronectin (FN1), vitronectin (VTN), and osteopontin (SPP1)
  • is a modular extracellular matrix protein that is essential for vertebrate development
  • is a major extracellular matrix protein implicated in cell adhesion and differentiation in the bone marrow (BM) environment
  • is a fundamental component of the hematopoietic tissue and the EIIIA exon may play a key role in modulating hematopiesis in conditions of BM stress or diseases
  • FN1 expression is an early and progressive event that occurs during liver fibrogenesis
  • plays a critical role in inflammasome-activated cells by amplifying caspase-1 activation and inducing inflammatory cell death
  • play roles in skeletal tissues through its secretion by osteoblasts, chondrocytes, and mesenchymal cells
  • likely a reduced amount of secreted fibronectin from chondrocytes could result in a deficient matrix network in cartilage
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , development , immunity/defense
    text adhesion, migration
    PATHWAY
    metabolism
    signaling
  • SOX2-FN1 axis is a key pathway in mediating the migration and invasion of ovarian cancer cells
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
  • heparin
    • protein
  • collagen, actin
  • binds BMP1-like proteinases and FN1 is an important determinant of the activity levels of BMP1-like proteinases
  • HAND2 pathway establishes an appropriate environment for cardiac fusion through negative modulation of FN1 levels
  • interaction between the NC4 domain of COL9A1 and FN1 may represent an interaction in cartilage that could contribute to the matrix integrity of the tissue
  • is potentially a critical mediator for TGFB-specific production balance of 2 major proteoglycans, aggrecan and versican, during chondrogenesis
  • synthesis of FN1 is mediated by a transcriptional complex consisting of NFATC1, SP7 and FOS
  • association between EPO and FN1 expression in glomerular mesangial cells
  • RHOA stimulates the production of FN1 by podocytes, specifically testing the role of nuclear factor of activated T cells (NFATC1)
  • NFATC1 mediates RHOA-induced FN1 upregulation in glomerular podocytes
  • interaction between fibronectin (FN1) and collagen
  • FN1 and its major receptor, ITGB1/ITGA5 are required for embryogenesis
  • BST1 binds FN1 with high affinity within its heparin-binding domains 1 and 2
  • fibronectin-derived homophilic binding peptide, anastellin, as an effective inhibitor of angiogenesis
  • a binding site in DPT for FN1 was identified as the DPT-4 (PHGQVVVAVRS) peptide, and the major binding site in FN1 for DPT was the 14th type III repeat (III14) domain
  • NME1/fibronectin axis represents a barrier to melanoma progression
  • TGM2 is involved in cell-matrix interactions through association with the extracellular matrix protein, fibronectin (FN1)
  • binding of TGM2 to the ECM of small intestinal tissue sections is the sum of binding to FN1 via its N-terminal domain and binding to an abundant, novel extracellular matrix (ECM) interaction partner via its second C-terminal beta-barrel domain
  • thyroid hormone regulates FN1 expression through the activation of the HIF1A
    • cell & other
  • bind cell surfaces and various compounds including fibrin, DNA
    • REGULATION
    induced by decreased DICER1 expression that induces FN1 expression via an EGR1-dependent manner
    Other degradation by LRP
    ASSOCIATED DISORDERS
    corresponding disease(s) EDS10 , GFND2 , SMDCF1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer cells
    tumoral       gain of function
    up-regulated in germ cells yolk sac tumors
    tumoral     --over  
    in renal cancer
    Susceptibility susceptibility to lung fibrosing alveolitis in systemic sclerosis
    Variant & Polymorphism
    Candidate gene
  • EPPIN-FN1 complex may involve in semen coagulation, liquefaction and the survival and preparation of spermatozoa for fertility in the female reproductive tract
    • Marker
  • FN1 mRNA expression might serve as a marker for renal cell cancer (RCC) aggressiveness, indicating early systemic progression particularly for patients with papillary RCC
  • serum- and CSF-FN1 levels constitute a potential clinical diagnostic biomarker for epilepsy and could also be used for differential diagnosis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    offers crucial molecular insights and promises to develop putative candidate therapeutic interventions in women with ovarian cancer
    ANIMAL & CELL MODELS