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FLASH GENE
Symbol TMEM102 contributors: mct - updated : 24-06-2016
HGNC name transmembrane protein 102
HGNC id 26722
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Tmem102 (78.9 pc)
homolog to murine Tmem102 (79.7 pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
text single-pass membrane protein
basic FUNCTION
  • modulating GM-CSF-deprivation-induced apoptosis possibly via a novel mechanism involving interaction with an un-liganded betac molecule
  • is a novel component in the TCR signaling pathway and modulates thymocyte apoptosis during negative selection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • indeed can function as a novel signaling component within the ZAP70/VAV1/talin complex and plays an important role in regulating chemokine-promoted T-cell trafficking (23620790)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cbap-deficient mice showed normal early thymocyte development and positive selection