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FLASH GENE
Symbol FGF5 contributors: sge/pgu - updated : 30-07-2010
HGNC name fibroblast growth factor 5
HGNC id 3683
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Fgf5 (87.5pc)
homolog to rattus Fgf5 (86.0pc)
intraspecies homolog to HST oncogene
Homologene
FAMILY
  • heparin-binding growth factors family
  • FGF4 subfamily
    • CATEGORY protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus
    text secreted
    basic FUNCTION
  • fibroblast growth factor 5, basic, oncogene, confering transforming potential when transfected into cells
  • contributes to the malignant progression of astrocytic brain tumors by both autocrine and paracrine effects
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism polymorphism is associated with attered susceptibility to hypertension
    Candidate gene for hypertrichosis universalis and hairy elbows
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    SNO is associated with hair length in dogs