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FLASH GENE
Symbol FGF5 contributors: sge/pgu - updated : 30-07-2010
HGNC name fibroblast growth factor 5
HGNC id 3683
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 splicing 5399 - 268 - -
  • isoform 1
  • precursor
    • 2 splicing 5295 - 123 - -
  • truncated isoform, isoform 2
  • precursor
  • naturally expressed partial agonist/antagonist of FGF5 neurotrophic activity in the brain
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelial    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, neonatal, pregnancy
    Text neonatal brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Fgf5 (87.5pc)
    homolog to rattus Fgf5 (86.0pc)
    intraspecies homolog to HST oncogene
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • FGF4 subfamily
    • CATEGORY protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus
    text secreted
    basic FUNCTION
  • fibroblast growth factor 5, basic, oncogene, confering transforming potential when transfected into cells
  • contributes to the malignant progression of astrocytic brain tumors by both autocrine and paracrine effects
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism polymorphism is associated with attered susceptibility to hypertension
    Candidate gene for hypertrichosis universalis and hairy elbows
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    SNO is associated with hair length in dogs