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FLASH GENE

Symbol

DEPDC1

contributors: mct - updated : 19-05-2022

HGNC name	DEP domain containing 1
HGNC id	22949

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001114120 12 - 5356 NP_001107592 93 811 - 2021 34210956 isoform a can form homo or heterodimer with isoform b NM_017779 11 - 4504 NP_060249 61.4 527 - 2021 34210956 isoform b can form homo or heterodimer with isoform a

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       predominantly Reproductive male system testis     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one DEP domain
	one Rho-GAP domain

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Depdc1a (83.0pc)
	homolog to rattus Depdc1 (82.5pc)

Homologene

FAMILY

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
text	is localized to the centrosome in metaphase
	predominantly localized in the nucleus during interphase and is redistributed into the whole cell upon nuclear membrane breakdown in metaphase

basic FUNCTION	playing an essential role in the growth of bladder cancer cells
	may be involved in intracellular signaling cascade, as a GTPase activator
	plays a pivotal role in the regulation of proper mitotic progression
	required for the integrity of centrosome and organization of the bipolar spindle
	novel role for DEPDC1 in maintaining centrosome integrity during mitosis for the accurate distribution of chromosomes
	plays an oncogenic role in lung adenocarcinoma (LUAD)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in bladder carcinoma tumoral     --over   at both mRNA and protein levels innasopharyngeal carcinoma (NPC) tissues compared with normal or non-tumor tissues tumoral     --over   in Colorectal cancer (CRC)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may act as a potential biomarker for CRC detection as well as a prognostic predictor concerning the survival of CRC patient
Therapy target
	System Type Disorder Pubmed cancer head and neck   may serve as a novel therapeutic target in NPC cancer reproductive prostate might be a potential therapeutic target against prostate carcinoma

ANIMAL & CELL MODELS