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FLASH GENE
Symbol ANO10 contributors: mct - updated : 17-10-2016
HGNC name anoctamin 10
HGNC id 25519
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highlyHomo sapiens
Nervousbrainforebraincerebral cortexfrontal cortexpredominantly Homo sapiens
 brainhindbraincerebellum   Homo sapiens
 brainforebraincerebral cortexoccipital cortex  Homo sapiens
Visualeyeretina  highlyHomo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • anoctamin family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • with ANO9, can suppress baseline Cl- conductance when co-expressed with ANO1
  • specific function in the adult mature brain and especially in the cerebral cortex and the cerebellum, rather than in brain development
  • involved in a variety of functions that include ion transport, phospholipid scrambling, and regulation of other membrane proteins
  • is likely essential for Ca(2+)-dependent Cl(-) secretion in jejunum
  • has a central role in innate immune defense against Borrelia infection
  • modulates Ca2+ signals in macrophages and has a role in cerebellar ataxia and other neurological disorders
  • ANO1 is responsible for basolateral Ca2+-dependent Cl- secretion in RPE, whereas ANO6 and ANO10 may have different functions, such as modulating Ca2+ signals
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCAR10
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS