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FLASH GENE

Symbol

ANO10

contributors: mct - updated : 17-10-2016

HGNC name	anoctamin 10
HGNC id	25519

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	325.27 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018075 13 - 2743 NP_060545 76.2 660 - 2014 24692353 NM_001204834 12 - 2173 NP_001191763 - 470 - 2014 24692353 NM_001204833 11 - 2410 NP_001191762 - 549 - 2014 24692353 NM_001204832 12 - 2545 NP_001191761 - 594 - 2014 24692353 NM_001204831 13 - 2746

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Nervous brain forebrain cerebral cortex frontal cortex predominantly Homo sapiens   brain hindbrain cerebellum     Homo sapiens   brain forebrain cerebral cortex occipital cortex   Homo sapiens Visual eye retina     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

anoctamin family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	with ANO9, can suppress baseline Cl- conductance when co-expressed with ANO1
	specific function in the adult mature brain and especially in the cerebral cortex and the cerebellum, rather than in brain development
	involved in a variety of functions that include ion transport, phospholipid scrambling, and regulation of other membrane proteins
	is likely essential for Ca(2+)-dependent Cl(-) secretion in jejunum
	has a central role in innate immune defense against Borrelia infection
	modulates Ca2+ signals in macrophages and has a role in cerebellar ataxia and other neurological disorders
	ANO1 is responsible for basolateral Ca2+-dependent Cl- secretion in RPE, whereas ANO6 and ANO10 may have different functions, such as modulating Ca2+ signals

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SCAR10

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS