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FLASH GENE
Symbol ANO9 contributors: mct - updated : 18-03-2025
HGNC name anoctamin 9
HGNC id 20679
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • anoctamin family
  • Ca(2+)-dependent lipid scramblases family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • with ANO10, can suppress baseline Cl- conductance when co-expressed with ANO1
  • is a scramblase that redistributes phospholipids across the cell membrane
  • ANO9 is a cation channel activated by a cAMP/PKA pathway and could play a role in intestine function
  • ANO9 regulates the cell cycle via centrosome-related genes in esophageal squamous cell carcinoma (ESCC)
  • ANO9 is important for mammalian olfactory transduction
  • controls the intracellular distribution of calcium, and inhibits intracellular receptor-mediated Ca2+ signals and Ca2+ -dependent activation of ion channels, but augments transcription and release of pro-inflammatory cytokines
  • important regulator of intracellular Ca2+ signals, ion channel activity, and cytokine release
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by is a cation channel activated by a cAMP-dependent protein kinase A (PKA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    up-regulation of ANO9, as a metastasis-related gene, could be a novel approach for inhibiting CRC progression
    ANIMAL & CELL MODELS