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FLASH GENE

Symbol

ANO9

contributors: mct - updated : 18-03-2025

HGNC name	anoctamin 9
HGNC id	20679

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001012302 23 - 2879 NP_001012302 90.2 782 - 2023 36520003 NM_001347882 22 - 2947 NP_001334811 - 638 - 2023 36520003

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine       highly Endocrine neuroendocrine pituitary     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	anoctamin family
	Ca(2+)-dependent lipid scramblases family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	with ANO10, can suppress baseline Cl- conductance when co-expressed with ANO1
	is a scramblase that redistributes phospholipids across the cell membrane
	ANO9 is a cation channel activated by a cAMP/PKA pathway and could play a role in intestine function
	ANO9 regulates the cell cycle via centrosome-related genes in esophageal squamous cell carcinoma (ESCC)
	ANO9 is important for mammalian olfactory transduction
	controls the intracellular distribution of calcium, and inhibits intracellular receptor-mediated Ca2+ signals and Ca2+ -dependent activation of ion channels, but augments transcription and release of pro-inflammatory cytokines
	important regulator of intracellular Ca2+ signals, ion channel activity, and cytokine release

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

is a cation channel activated by a cAMP-dependent protein kinase A (PKA)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon up-regulation of ANO9, as a metastasis-related gene, could be a novel approach for inhibiting CRC progression

ANIMAL & CELL MODELS