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FLASH GENE
Symbol ANO9 contributors: mct - updated : 18-03-2025
HGNC name anoctamin 9
HGNC id 20679
Location 11p15.5      Physical location : 417.929 - 442.011
Synonym name
  • tumor protein p53 inducible protein 5
  • transmembrane protein 16J
    • Synonym symbol(s) TP53I5, TMEM16J, PIG5, PIG5,
    DNA
    TYPE functioning gene
    STRUCTURE 24.08 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 2879 90.2 782 - 2023 36520003
    22 - 2947 - 638 - 2023 36520003
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestine   highly
    Endocrineneuroendocrinepituitary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • anoctamin family
  • Ca(2+)-dependent lipid scramblases family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • with ANO10, can suppress baseline Cl- conductance when co-expressed with ANO1
  • is a scramblase that redistributes phospholipids across the cell membrane
  • ANO9 is a cation channel activated by a cAMP/PKA pathway and could play a role in intestine function
  • ANO9 regulates the cell cycle via centrosome-related genes in esophageal squamous cell carcinoma (ESCC)
  • ANO9 is important for mammalian olfactory transduction
  • controls the intracellular distribution of calcium, and inhibits intracellular receptor-mediated Ca2+ signals and Ca2+ -dependent activation of ion channels, but augments transcription and release of pro-inflammatory cytokines
  • important regulator of intracellular Ca2+ signals, ion channel activity, and cytokine release
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by is a cation channel activated by a cAMP-dependent protein kinase A (PKA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    up-regulation of ANO9, as a metastasis-related gene, could be a novel approach for inhibiting CRC progression
    ANIMAL & CELL MODELS