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FLASH GENE
Symbol F11 contributors: mct/npt - updated : 14-04-2010
HGNC name coagulation factor XI
HGNC id 3529
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
  • peptidase S1 family
  • plasma kallikrein subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
    basic FUNCTION
  • triggering the middle phase of the intrinsic pathway of blood coagulation by activating factor IX
  • promotes hemostasis and thrombosis through enhancement of thrombin generation and may play a critical role in the formation of occlusive thrombi in arterial injury models (White-Adams 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer consisting of two identical polypeptide chains linked by disulfide bonds and during activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LRP8 (a platelet receptor for FXI) (White-Adams 2009)
    • cell & other
    REGULATION
    activated by FXIIa producing a serine protease composed of two heavy and two light chains
    FXIIa and thrombin (dimeric structure of FXI is essential for normal proteolytic activation of FXI by FXIIa, thrombin, or FXIa either in solution or on an anionic surface but not for FIX activation by FXIa in solution)(Wu 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) F11
    Susceptibility high levels of F11 representing a risk factor for deep venous thrombosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS