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FLASH GENE
Symbol BSX contributors: mct - updated : 14/11/2008
HGNC name brain-specific homeobox
HGNC id 20450
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA-binding domain
    • HOMOLOGY
    interspecies homolog to chimpanzee BSX (99.6 pc)
    homolog to rattus Bsx (94.8 pc)
    homolog to murine Bsw (96.1 pc)
    Homologene
    FAMILY
  • distal-less homeobox family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • functioning as transcriptional activator
  • being essentiel for normal postnatal growth and nursing
  • being an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance
  • important molecular marker for early embryonic stages of epiphysis development, being specifically expressed in this neural structure (Cremona 2004)
  • required for locomotory behavior, hyperphagia, and expression of the hypothalamic neuropeptides Npy and Agrp, which regulate feeding behavior and body weight (sakkou 2007)
  • essential factor for NPY/AgRP neuronal function and locomotory behavior in the control of energy balance (Sakkou 2007)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to specific sequence
    RNA
    small molecule
    protein
  • AGRP is a common orexigenic target gene of NR3C1 and BSX
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS