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FLASH GENE
Symbol DNAJB8 contributors: npt - updated : 22/10/2008
HGNC name DnaJ (Hsp40) homolog, subfamily B, member 8
HGNC id 23699
DNA
TYPE functioning gene
STRUCTURE 4.81 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2479 26 232 - -
EXPRESSION
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a glycine/phenylalanine (G/F)-rich region
  • a cysteine-rich domain
  • four motifs resembling a zinc finger domain
    • HOMOLOGY
    Homologene
    FAMILY
  • DNAJ/HSP40 family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • with DNAJB6 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins
  • DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS