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FLASH GENE
Symbol GRIK1 contributors: mct - updated : 20-10-2015
HGNC name glutamate receptor, ionotropic, kainate 1
HGNC id 4579
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Endocrineadrenal gland   highly
Hearing/Equilibriumear   predominantly
Nervousbrainlimbic systemhippocampus   Homo sapiens
 braindiencephalonhypothalamussuprachiasmatic nuclei 
 brainhindbraincerebellum  
Reproductivefemale systemplacenta  moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 30 aa signal peptide (3.5 kda)
  • four transmembrane segments (4TM)
    • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to rattus Grik1 (97.2pc)
    ortholog to murine Grik1 (97.8pc)
    Homologene
    FAMILY
  • glutamate-gated ion channel (TC 1.A.10) family
    • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text
  • postsynaptic membrane
    • basic FUNCTION
  • may be involved in the transmission of light information from the retina to the hypothalamus
  • during ischemia-reperfusion, activated GRIK1 may facilitate Ca(2+)-dependent GABA release from interneurons
  • plays a role as an excitatory regulator of synaptic transmission and plasticity
  • its function is mainly associated with mossy fiber sprouting
  • inhibits calcium dependent and independent transmitter release at associational/commissural synapses in the hippocampus
  • kainate receptor subunit in the ionotropic glutamate receptor family and can form functional channels
  • activation of postsynaptic GRIK1-containing presynaptic kainate receptors (KARs) on vasopressin (VP) neurons leads to the release of dynorphin, which in turn acts on presynaptic kappa-opioid receptors to inhibit glutamate release
  • its overexpression is sufficient to enhance kainate receptor activity by modulating receptor channel properties, but not localization
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • ion transport
  • central nervous system development
    • PATHWAY
    metabolism
    signaling signal transduction
  • glutamate signaling pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GRIK2, GRIK5 AND KIF17
  • GRIK1, GRIK2, interact with the spectrin-actin binding scaffolding protein EPB41L1 through a membrane-proximal domain in the C-terminal tail
    • cell & other
  • domoate
  • kainate
  • L-glutamate
  • quisqualate
  • CNQX
  • DNQX
  • AMPA
  • dihydrokainate
  • NMDA
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the hippocampus, but not in the temporal neocortex, of patients with temporal lobe epilepsy compared to the control group
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS