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FLASH GENE
Symbol GRIK1 contributors: mct - updated : 20-10-2015
HGNC name glutamate receptor, ionotropic, kainate 1
HGNC id 4579
Location 21q21.3      Physical location : 30.909.255 - 31.312.282
Synonym name
  • excitatory amino acid receptor 3
  • glutamate receptor 5
    • Synonym symbol(s) GLUR5, EEA3, EAA3, GLR5, GluK1
    DNA
    TYPE functioning gene
    STRUCTURE 403.03 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D21S226 - {D21S1685 - D21S1845 - D21S1703 - D21S213 - D21S300 - D21S1699 - D21S1236 ] - qter
    Authors Gregor (93, 94), Orti (97), Ohira (98), Barbon (00)
    Text [GRIK1 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 splicing 3231 - 918 - 1995 8589992
  • also known as GluR5-1D
  • 17 exons
  • a 30 aa signal peptide (3.5 kda)
  • a 888 aa mature peptide (100.5 kda)
    • 16 splicing 3489 - 905 - 1995 8589992
  • also known as EAA3A
  • 16 exons
  • lacking an in-frame exon and differing in the 3' coding region compared to variant 1
  • a 30 aa signal peptide (3.5 kda)
  • a 87 aa mature peptide (99.1 kda)
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Endocrineadrenal gland   highly
    Hearing/Equilibriumear   predominantly
    Nervousbrainlimbic systemhippocampus   Homo sapiens
     braindiencephalonhypothalamussuprachiasmatic nuclei 
     brainhindbraincerebellum  
    Reproductivefemale systemplacenta  moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 30 aa signal peptide (3.5 kda)
  • four transmembrane segments (4TM)
    • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to rattus Grik1 (97.2pc)
    ortholog to murine Grik1 (97.8pc)
    Homologene
    FAMILY
  • glutamate-gated ion channel (TC 1.A.10) family
    • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text
  • postsynaptic membrane
    • basic FUNCTION
  • may be involved in the transmission of light information from the retina to the hypothalamus
  • during ischemia-reperfusion, activated GRIK1 may facilitate Ca(2+)-dependent GABA release from interneurons
  • plays a role as an excitatory regulator of synaptic transmission and plasticity
  • its function is mainly associated with mossy fiber sprouting
  • inhibits calcium dependent and independent transmitter release at associational/commissural synapses in the hippocampus
  • kainate receptor subunit in the ionotropic glutamate receptor family and can form functional channels
  • activation of postsynaptic GRIK1-containing presynaptic kainate receptors (KARs) on vasopressin (VP) neurons leads to the release of dynorphin, which in turn acts on presynaptic kappa-opioid receptors to inhibit glutamate release
  • its overexpression is sufficient to enhance kainate receptor activity by modulating receptor channel properties, but not localization
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • ion transport
  • central nervous system development
    • PATHWAY
    metabolism
    signaling signal transduction
  • glutamate signaling pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GRIK2, GRIK5 AND KIF17
  • GRIK1, GRIK2, interact with the spectrin-actin binding scaffolding protein EPB41L1 through a membrane-proximal domain in the C-terminal tail
    • cell & other
  • domoate
  • kainate
  • L-glutamate
  • quisqualate
  • CNQX
  • DNQX
  • AMPA
  • dihydrokainate
  • NMDA
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the hippocampus, but not in the temporal neocortex, of patients with temporal lobe epilepsy compared to the control group
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS