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FLASH GENE
Symbol HSPB11 contributors: npt/mct - updated : 29-08-2017
HGNC name heat shock protein family B (small), member 11
HGNC id 25019
Location 1p33-p32.1      Physical location : 54.387.235 - 54.411.288
Synonym name
  • chromosome 1 open reading frame 41
  • small heat shock-like protein-Hsp16.2
  • Synonym symbol(s) C1orf41, HSPCO34, PP25, IFT25
    DNA
    TYPE functioning gene
    STRUCTURE 24.05 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 601 16.2 144 - Bellyei (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     parathyroid   highly
    Reproductivemale systemtestis  highly Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress , unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • formed oligomeric complexes in aqueous solution
  • could be modified covalently by poly(ADP ribosylation) and acetylation
  • can prevent the destabilization of mitochondrial membrane systems and could represent a suitable target for modulating cell death pathways
  • may have relevance as becoming a possible tumor marker
  • although not necessary for the formation of cilia in somatic cells, is likely indispensable for sperm flagellum formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the IFT complex not required for the formation of cilia in somatic tissues
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSPB11 directly interacts with IFT27, and these two proteins likely form a subcomplex (association and disassociation between the subcomplex of HSPB11 and IFT27 and complex B might be involved in the regulation of IFT)
  • IFT52 binds directly to four other IFT-B subunits, IFT81/74/27/HSPB11
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    displayed increased expression in neuroectodermal tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS