Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

PCK1

contributors: mct - updated : 15-05-2020

HGNC name	phosphoenolpyruvate carboxykinase 1 (soluble)
HGNC id	8724

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PCKDC

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   lower in clinical hepatocellular carcinoma (HCC) tissues than that in normal tissues

Susceptibility

to type 2 diabetes mellitus to late-onset Alzheimer's disease

Variant & Polymorphism SNP	promoter SNP associated with type 2 diabetes mellitus

Candidate gene
Marker	PCK1 may serve as a candidate prognostic biomarker in clear cell renal cell carcinoma (ccRCC)
Therapy target
	System Type Disorder Pubmed cancer urinary   targeting the PCK1/LDHA pathway might be a new strategy to selectively inhibit tumor metabolism in in clear cell renal cell carcinoma cancer digestive colon DHODH and PCK1 are metabolic therapeutic targets in Colorectal metastatic progression

ANIMAL & CELL MODELS