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FLASH GENE

Symbol

CCND1

contributors: mct/ - updated : 02-08-2021

HGNC name	cyclin D1
HGNC id	1582

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BCL1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       fused with TACSTD2 in cancer cells, fused with Igh in t(11;14) (q13;q32) tumoral   amplification     amplified in mantle cell lymphoma(same as BCL1, D11S287E), endometrial cancer tumoral     --low   in T-cell leukemia tumoral   translocation     t(6;11)(p21;q13), t(1;11)(p13;q13), t(7;11)(q11.2;q13), and t(5;11)(q35; q13) in renal oncocytoma tumoral     --over   in parathyroid adenoma, breast (stimulatory effect of estradiol and prolactin) carcinoma tumoral   amplification     coamplified with SHANK2, and CTT1 in oral squamous cell carcinoma tumoral   deletion     deletion in mantle cell lymphoma, associated with increased proliferation rate and shorter survival tumoral   translocation     in parathyroid adenomas tumoral   amplification     in breast cancer, alone or with PPFIA1 constitutional     --over   perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells

Susceptibility

to colorectal carcinoma (non polyposis) to lung cancer in smokers from north India to HELLP syndrome

Variant & Polymorphism	polymorphism modifying the age at onset of colorectal cancer
	A870G gene polymorphisms may increase the risk of lung cancer in smokers from north India

Candidate gene	polymorphisms N363S associated with the development of HELLP syndrome
Marker	biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
Therapy target
	System Type Disorder Pubmed cancer     targeting CCND1 may be beneficial also in retinoblastoma-negative cancers which are currently thought to be unaffected by CCND1 inhibition cancer     targeting CCND1 is a promising strategy for preventing tumor progression and combating therapy resistance in cancer

ANIMAL & CELL MODELS