Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TKT

contributors: npt/mct - updated : 04-07-2016

HGNC name	transketolase
HGNC id	11834

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

WKS , CHDRSS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function in cases with diabetic neuropathy constitutional       loss of function in cases with alcoholic neuropathy

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary ould be used as novel therapeutic target for advanced disease

ANIMAL & CELL MODELS

TKT-null mouse embryos are not viable and disruption of one TKT allele can cause growth retardation and preferential reduction of adipose tissue (Xu 2002)