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FLASH GENE
Symbol DBNDD1 contributors: mct/npt/pgu - updated : 07-01-2022
HGNC name dysbindin (dystrobrevin binding protein 1) domain containing 1
HGNC id 28455
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Dbndd1 (81.9 pc)
homolog to murine Dbndd1 (80.7 pc)
Homologene
FAMILY
  • dysbindin family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functions presynaptically, potentially at or near the synaptic vesicle pool
  • required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx
  • essential for adaptive neural plasticity and may link altered homeostatic signaling with a complex neurological disease
  • possible functions of DBNDD1 at the postsynapse in the regulation of dendritic spine morphogenesis through the interaction with WASF2 and ABI1)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CMYA5 is a TRIM-like protein associated protein dysbindin (DBNDD1)
    • cell & other
    REGULATION
    Other regulated by TRIM32 (TRIM32 binds and ubiquitinates dysbindin, a protein implicated in the genetic aetiology of schizophrenia, augmenting its degradation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia
    Variant & Polymorphism other contribution of dysbindin mutations to schizophrenia may derive from altered homeostatic plasticity as opposed to decreased baseline glutamatergic transmission
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS