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FLASH GENE

Symbol

BMP7

contributors: mct/npt - updated : 21-03-2016

HGNC name	bone morphogenetic protein 7
HGNC id	1074

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer tumoral   amplification     in breast cancer tumoral     --over   in myelofibrosis tumoral     --low   in primary breast cancer is significantly associated with the formation of clinically overt bone metastases

Susceptibility

to hypospadias

Variant & Polymorphism other	polymorphism increasing the risk of hypospadias

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed obesity     . potential new therapeutic approach for the treatment of obesity (treatment with BMP7 or its molecular mimetic may activate brown fat differentiation, leading to an increase in energy expenditure, and thereby providing a new way to combat obesity cancer reproductive breast . may represent a novel therapeutic molecule for repression of local and bone metastatic growth of breast cancer miscelleaneous urinary   possible treatment for reversing end-stage renal disease

ANIMAL & CELL MODELS

Bmp7-deficient mice exhibit substantially diminished Langerhans cell (LC) numbers, with the remaining cells appearing less dendritic