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FLASH GENE
Symbol CRIPAK contributors: mct/npt - updated : 07/10/2008
HGNC name cysteine-rich PAK1 inhibitor
HGNC id 26619
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 13 zinc-finger domains
  • three trypsin inhibitor-like
  • cysteine-rich domains
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • negative regulator of the PAK1 that has a role in the modulation of PAK1-mediated ER transactivation in breast cancer cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • negative regulator of PAK1 (interacted with PAK1 through the N-terminal regulatory domain and inhibited PAK1 kinase)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS