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FLASH GENE

Symbol

CRIPAK

contributors: mct/npt - updated : 07/10/2008

HGNC name	cysteine-rich PAK1 inhibitor
HGNC id	26619

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4p16.3      Physical location : 1.385.339 - 1.389.782
Synonym symbol(s)	FLJ34443, MGC150528

DNA

TYPE	functioning gene
STRUCTURE	4.44 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CRIPAK 1 - 4467 48.1 446 - Talukder (2006)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine neuroendocrine pituitary     highly Lymphoid/Immune spleen       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	13 zinc-finger domains
	three trypsin inhibitor-like
	cysteine-rich domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus

basic FUNCTION

negative regulator of the PAK1 that has a role in the modulation of PAK1-mediated ER transactivation in breast cancer cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

negative regulator of PAK1 (interacted with PAK1 through the N-terminal regulatory domain and inhibited PAK1 kinase)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS