Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EGFLAM contributors: mct/npt - updated : 24/09/2008
HGNC name EGF-like, fibronectin type III and laminin G domains
HGNC id 26810
Location 5p13.2-p13.1      Physical location : 38.258.532 - 38.465.581
Synonym name pikachurin
Synonym symbol(s) AGRNL, AGRINL, FLJ39155
DNA
TYPE functioning gene
STRUCTURE 207.05 kb     22 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 3952 - 1009 - Sato (2008)
17 - 4142 - 775 - Sato (2008)
12 - 3328 - 375 - Sato (2008)
- - 2228 - 152 - Sato (2008)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousnerve   highly
Reproductivefemale systemplacenta  highly
 male systemprostate  highly
Visualeye   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text in developing photoreceptors
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • laminin G and EGF-like domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text localized to the synaptic cleft in the photoreceptor ribbon synapse
    basic FUNCTION
  • extracellular matrix–like retinal protein, dystroglycan-interacting protein and has an essential role in the precise interactions between the photoreceptor ribbon synapse and the bipolar dendrites
  • required for apposition of bipolar dendrite, and for synaptic signal transmission
  • functioning specifically in photoreceptor-bipolar synaptic apposition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • colocalized with both dystrophin and dystroglycan at the ribbon synapses
  • dystroglycan ligand in the retina
  • cell & other
    REGULATION
    Other regulated by OTX2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS