protein
| agrin |
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laminin A/B1/B2 and merosin M/B1/B2 |
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laminin-1 |
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dystrophin |
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Biglycan |
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utrophin |
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growth factor receptor 2, Grb2 |
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Caveolin-3 |
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rapsyn RING-H2 domain |
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AGR2 and AGR3 |
|
AGR |
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DAG1 function requires xylosyl- and glucuronyltransferase activities of LARGE to bind laminin-G domain-containing ECM ligands |
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CHST10 suppressed the glycosylation and reduced the ligand binding activity of DAG1 |
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sulfate transfer induced by CHST10 plays a regulatory role in the formation of functional glycans DAG1 |
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GYLTL1B regulates functional DAG1 glycosylation in prostate cancer cell lines |
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POMGNT2 might encode O-GlcNAc transferase that specifically glycosylates DAG1 |
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interacts with DAG1 and controls motility and mechanical properties of Schwann cells |
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POMGNT1 stem region modulates O-mannosylation sites of DAG1, by its carbohydrate-binding domain |
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TRAPPC11 and another membrane trafficking protein, GOSR2, implicated in DAG1 hypoglycosylation |
| Heterozygous Dag1neo2 mice are viable and fertile but homozygous Dag1neo2 embryos exhibit gross developmental abnormalities beginning around 6.5 days of gestation that is due to a disruption of Reichert's membrane | |
chimaeric mice generated with ES cells targeted for both dystroglycan alleles have skeletal muscles essentially devoid of dystroglycans and develop a progressive muscle pathology with many disrupted neuromuscular junctions |
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brain-selective deletion of dystroglycan in mice is sufficient to cause congenital muscular dystrophie-like brain malformations, including disarray of cerebral cortical layering, fusion of cerebral hemispheres and cerebellar folia, and aberrant migration of granule cells |
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striated muscle-specific disruption of the mouse Dag1 gene results in loss of the dystrophin-glycoprotein complex in differentiated muscle and a remarkably mild muscular dystrophy with hypertrophy and without tissue fibrosis |
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mouse harboring the Dag1 Thr192Met mutation display muscular dystrophy and cognitive impairment |
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Dg morpholino knockdown leads to disruption of epidermal differentiation by affecting the intercalation of multiciliated cells, deposition of laminin, and organization of fibronectin in the extracellular matrix |
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disruption of dystroglycan-Laminin interactions result in decreased filopodial number and length, decreased process length, and decreased numbers of primary and secondary processes |