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FLASH GENE
Symbol SEMG1 contributors: mct - updated : 13-02-2018
HGNC name semenogelin I
HGNC id 10742
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Syp1
Homologene
FAMILY semenogelin family
CATEGORY secretory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,nucleus
basic FUNCTION
  • formation of a gel matrix entrapping the accessory gland secretion and ejaculated spermatozoa
  • antibacterial activity of the SEMG1-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH
  • in sperm modifies the membrane structure, indirectly inhibiting motility
  • EPPIN and SEMG1 rapidly co-evolved in primates due to their critical role in the modulation of sperm motility in the semen coagulum
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component major constituent protein of seminal fluid
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • rapidly cleaved after ejaculation by KLK3, resulting in liquefaction of the semen coagulum and
    • the progressive release of motile spermatozoa
  • binding semenogelins II and zinc and regulate the activity of prostate-specific antigen (KLK3)
  • cleaved by KLK14
  • during ejaculation SEMG (semenogelin) from the seminal vesicles binds to the EPPIN protein complex, initiating a series of events that define EPPIN function
  • EPPIN controls sperm motility in the ejaculate by binding SEMG1, resulting in the loss of calcium, most likely through a disturbance of internal pH and an inhibition of uptake mechanisms
  • EPPIN's sequence C102-P133 contains the major binding site for SEMG1
  • interaction between PIP and SEMG1 fragments in seminal plasma or elsewhere with a suggestive role in reproductive physiology which might be helpful for spermatozoa to acquire their motility
  • physiological significance of the SEMG1/EPPIN interaction on the surface of spermatozoa is its capacity to modulate sperm progressive motility
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in nearly half of patients with early Chronic lymphocytic leukemia (CLL)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for the development of diagnostic marker and provided the opportunity to further illustrate the biological mechanisms of asthenozoosperm
    • Marker
  • use of SEMG1 as a novel biomarker for renal cell carcinoma
    • Therapy target
    ANIMAL & CELL MODELS