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FLASH GENE

Symbol

SEMG1

contributors: mct - updated : 13-02-2018

HGNC name	semenogelin I
HGNC id	10742

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
text	located 5' to SEMG2 in a head to tail arrangement
STRUCTURE	2.80 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

tightly linked to SEMG2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003007 3 - 1696 NP_002998 - 462 - 2013 24312623

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system seminal vesicles     highly   male system male genital tract epididymis       male system prostate         male system male genital tract vas deferens     Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines
fluid/secretion	in human semen coagulum

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Syp1

Homologene

FAMILY

semenogelin family

CATEGORY

secretory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,nucleus

basic FUNCTION	formation of a gel matrix entrapping the accessory gland secretion and ejaculated spermatozoa
	antibacterial activity of the SEMG1-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH
	in sperm modifies the membrane structure, indirectly inhibiting motility
	EPPIN and SEMG1 rapidly co-evolved in primates due to their critical role in the modulation of sperm motility in the semen coagulum

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

major constituent protein of seminal fluid

INTERACTION

DNA

RNA

small molecule

protein	rapidly cleaved after ejaculation by KLK3, resulting in liquefaction of the semen coagulum and
	the progressive release of motile spermatozoa
	binding semenogelins II and zinc and regulate the activity of prostate-specific antigen (KLK3)
	cleaved by KLK14
	during ejaculation SEMG (semenogelin) from the seminal vesicles binds to the EPPIN protein complex, initiating a series of events that define EPPIN function
	EPPIN controls sperm motility in the ejaculate by binding SEMG1, resulting in the loss of calcium, most likely through a disturbance of internal pH and an inhibition of uptake mechanisms
	EPPIN's sequence C102-P133 contains the major binding site for SEMG1
	interaction between PIP and SEMG1 fragments in seminal plasma or elsewhere with a suggestive role in reproductive physiology which might be helpful for spermatozoa to acquire their motility
	physiological significance of the SEMG1/EPPIN interaction on the surface of spermatozoa is its capacity to modulate sperm progressive motility

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in nearly half of patients with early Chronic lymphocytic leukemia (CLL)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate gene for the development of diagnostic marker and provided the opportunity to further illustrate the biological mechanisms of asthenozoosperm
Marker	use of SEMG1 as a novel biomarker for renal cell carcinoma
Therapy target

ANIMAL & CELL MODELS