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FLASH GENE

Symbol

BCL6

contributors: mct/pgu - updated : 10-04-2016

HGNC name	B-cell CLL/lymphoma 6
HGNC id	1001

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FL3B

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     in B cell lymphomas, translocations t(3;14), t(3;13),t(2;3),t(3;22),t(3;4),t(3;11)and others tumoral fusion       in primary diffuse large B-cell lymphomas of the central nervous system with poor prognosis tumoral fusion       fused with histone H4 in t(3;6)(q27;p21), in non-Hodgkin's lymphoma tumoral   translocation     with HSPCA and GAPD in primary diffuse large B-cell lymphomas of the central nervous system tumoral   translocation     alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B tumoral somatic mutation       somatic point mutations in non-Hodgkin lymphomas (NHL) tumoral     --other   expressed in systemic anaplastic large cell lymphomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   combination modalities targeting the multiple oncogenic activities of BCL6 and the anti-apoptotic function of BCL2 may represent a rational approach for the treatment of a subset of DLBCL cancer hemopathy   dual targeting of oncogenic tyrosine kinases and BCL6-dependent feedback represents a novel strategy to eradicate drug-resistant and leukaemia-initiating subclones in tyrosine-kinase-driven leukaemia

ANIMAL & CELL MODELS