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FLASH GENE
Symbol POU1F1 contributors: /mct - updated : 06-10-2021
HGNC name POU class 1 homeobox 1
HGNC id 9210
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three main domains, an N-terminal transcription activation domain (TAD), and within the TAD, a beta-domain can be inserted by alternative splicing, giving an extended 'beta-variant' with altered properties
  • a POU-specific domain
  • a C-terminal homeodomain
    • HOMOLOGY
    interspecies homolog to Drosophila bicoid
    homolog to murine Pit1
    intraspecies homolog to POU3F3
    Homologene
    FAMILY
  • POU transcription factor family
  • class 1 subfamily
    • CATEGORY DNA associated , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the specification of the lactotrope, somatotrope and thyrotrope phenotypes in the developing anterior pituitary
  • phosphate transporter involved in regulated phosphate handling in bone forming cells
  • role of POU1F1 upregulation by HMGA proteins in pituitary tumours
  • serves essential functions in the differentiation and proliferation of somatotropes, lactotropes and thyrotropes
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • ETS1 (interactions regulated by phosphorylation of POU1F1)
  • binding PITX2
  • reciprocally interacting with GATA2 for the mediation of signaling gradient-induced determination of pituitary cell types
  • interacting with ANKH (Wang 2009)
  • POU1F1 is a transcription factor that regulates TFPI transcription in response to ADTRP
  • POU1F1 induces a metabolic reprogramming through LDHA regulation in breast tumor cells, modifying the phenotype of both cancer cells and fibroblasts to promote cancer progression
    • cell & other
    REGULATION
    Other expressed with POMC in a subset of adult anterior pituitary cells
    ASSOCIATED DISORDERS
    corresponding disease(s) CPHD1
    Susceptibility
  • to mental retardation, mild and borderline in females
  • to coronary artery disease (CAD)
    • Variant & Polymorphism SNP , other
  • increasing the risk of mental retardation, mild and borderline in females
  • POU1F1 variants associated to risk of CAD
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS