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FLASH GENE
Symbol CCKAR contributors: - updated : 28-02-2007
HGNC name cholecystokinin A receptor
HGNC id 1570
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • stimulating the phosphatidylinositol cycle, pancreatic enzyme secretion and dopamine-mediated behaviors
  • major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach
  • regulates satiety and the release of beta-endorphin and dopamine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral , digestion
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein CCK,GAS
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to variation of intelligence
  • to alcolholic dependence
    • Variant & Polymorphism SNP , other
  • G>T 5'utr, putatively involved in proportion of body fat content
  • promoter polymorphism increasing or decreasing the intelligence
  • 81A/G polymorphism, especially in the -81G allele, may be associated with intractable alcoholism.
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS