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FLASH GENE
Symbol CCDC115 contributors: mct - updated : 24-02-2016
HGNC name coiled-coil domain containing 115
HGNC id 28178
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two predicted coiled-coil domains
    • HOMOLOGY
    interspecies homolog to to yeast V-ATPase assembly factor Vma22p
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • downstream gene of fibroblast growth factor 2 (FGF2) highly expressed in embryonic and adult brain
  • regulates cell number by promoting proliferation and suppressing cell death
  • role for CCDC115 in Golgi trafficking
  • has likely a role in protein cargo sorting or trafficking of alkaline phosphatase in addition to a possible role in V-ATPase assembly
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be a downstream effecter of FGF2, promoting cell proliferation and protecting from apoptosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2O
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS