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FLASH GENE

Symbol

CCDC115

contributors: mct - updated : 24-02-2016

HGNC name	coiled-coil domain containing 115
HGNC id	28178

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032357 5 - 2000 NP_115733 19.7 180 - 2010 21118521

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens Adult   brain         Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two predicted coiled-coil domains

HOMOLOGY

interspecies

homolog to to yeast V-ATPase assembly factor Vma22p

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	downstream gene of fibroblast growth factor 2 (FGF2) highly expressed in embryonic and adult brain
	regulates cell number by promoting proliferation and suppressing cell death
	role for CCDC115 in Golgi trafficking
	has likely a role in protein cargo sorting or trafficking of alkaline phosphatase in addition to a possible role in V-ATPase assembly

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

may be a downstream effecter of FGF2, promoting cell proliferation and protecting from apoptosis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDG2O

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS