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FLASH GENE
Symbol MEIOB contributors: mct - updated : 13-04-2021
HGNC name meiosis-specific with OB domain-containing protein
HGNC id 28569
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an OB domain with homology to one of the RPA1 OB folds
  • single-strand DNA binding sites similar to those of RPA1
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • appeared to be dispensable for the initial loading of recombinases but was required to maintain a proper number of RAD51 and DMC1 foci beyond the zygotene stage
  • RPA1 and this new single-strand DNA binding protein MEIOB, are essential to ensure the proper stabilization of recombinases which is required for successful homology search and meiotic recombination
  • meiosis-specific protein, that binds to single-stranded DNA and exhibits 3prime-5prime exonuclease activity
  • potentially required for meiotic recombination and chromosomal synapsis
  • MEIOB and SPATA22 are recruited to induced DNA double-strand breaks (DSBs) together but not alone
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MEIOB forms a complex with RPA2 and with SPATA22, and these three proteins co-localize in foci that are associated with meiotic chromosome
  • MEIOB and SPATA22 form an obligate complex and contain defined interaction domains
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    protein
  • production of MEIOB is decreased in the absence of SPATA22, suggesting that SPATA22 is required for both meiotic recombination and synapsis during meiosis
  • MEIOB, a meiosis-specific single-stranded DNA-binding homolog of replication protein A1 (RPA1), is essential for meiotic recombination
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF22
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    a truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Meiob-null mouse mutants exhibit a failure in meiosis and sterility in both sexes