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FLASH GENE

Symbol

MEIOB

contributors: mct - updated : 13-04-2021

HGNC name	meiosis-specific with OB domain-containing protein
HGNC id	28569

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SPGF22 spermatogenic failure 22
Location	16p13.3      Physical location : -
Synonym name	hypothetical protein LOC254528
	chromosome 16 open reading frame 73
Synonym symbol(s)	MGC35212, gs129, C16orf73, SPGF22

DNA

TYPE	functioning gene
STRUCTURE	38.19 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001163560 11 - 1884 NP_001157032 - 471 - 2013 24068956 NM_152764 13 - 1731 NP_689977 - 442 - 2013 24068956

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an OB domain with homology to one of the RPA1 OB folds
	single-strand DNA binding sites similar to those of RPA1

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	appeared to be dispensable for the initial loading of recombinases but was required to maintain a proper number of RAD51 and DMC1 foci beyond the zygotene stage
	RPA1 and this new single-strand DNA binding protein MEIOB, are essential to ensure the proper stabilization of recombinases which is required for successful homology search and meiotic recombination
	meiosis-specific protein, that binds to single-stranded DNA and exhibits 3prime-5prime exonuclease activity
	potentially required for meiotic recombination and chromosomal synapsis
	MEIOB and SPATA22 are recruited to induced DNA double-strand breaks (DSBs) together but not alone

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	MEIOB forms a complex with RPA2 and with SPATA22, and these three proteins co-localize in foci that are associated with meiotic chromosome
	MEIOB and SPATA22 form an obligate complex and contain defined interaction domains

INTERACTION

DNA

RNA

small molecule

metal binding,

protein	production of MEIOB is decreased in the absence of SPATA22, suggesting that SPATA22 is required for both meiotic recombination and synapsis during meiosis
	MEIOB, a meiosis-specific single-stranded DNA-binding homolog of replication protein A1 (RPA1), is essential for meiotic recombination

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF22

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       a truncating MEIOB mutation responsible for familial primary ovarian insufficiency abolishes its interaction with its partner SPATA22

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Meiob-null mouse mutants exhibit a failure in meiosis and sterility in both sexes