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FLASH GENE
Symbol BRK1 contributors: mct - updated : 27-10-2017
HGNC name BRICK1, SCAR/WAVE actin nucleating complex subunit
HGNC id 23057
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • playing a role in nervous system development
  • essential role for this protein in actin dynamics
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RETREG3, BRK1 and ENOX1 are regulated by NRF1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small cell lung cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS