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FLASH GENE
Symbol BRK1 contributors: mct - updated : 27-10-2017
HGNC name BRICK1, SCAR/WAVE actin nucleating complex subunit
HGNC id 23057
Location 3p25.3      Physical location : -
Synonym name
  • Brk1-like protein
  • chromosome 3 open reading frame 10
  • haematopoietic stem/progenitor cell protein 300
    • Synonym symbol(s) MDS027, HSPC300, hHBrk1, C3orf10
    DNA
    TYPE functioning gene
    STRUCTURE 11.54 kb     3 Exon(s)
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • a functional and positive Sp1 regulatory element from -73 to -64 nt in the BRK1 promoter, which may likely explain the overexpression of BRK1 in non-small cell lung cancer (NSCLC)
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1197 8 75 - 2013 23939472
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • playing a role in nervous system development
  • essential role for this protein in actin dynamics
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RETREG3, BRK1 and ENOX1 are regulated by NRF1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small cell lung cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS