| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
|
|
in breast cancer cells, malignant breast tumor and metastases |
| tumoral
|
|
| --over
|
|
|
in metastatic renal clear cell carcinoma |
| constitutional
|
|
| --other
|
|
|
aberrantly expressed in pathological specimens of vitreoretinal membranes |
| tumoral
|
|
| --over
|
|
|
in melanoma cells in primary lesions, significantly associated with the presence of ulceration, increased tumor thickness, a greater risk of developing regional and distant metastases and a higher mortality rate |
| constitutional
|
|
|
| loss of function
|
|
enhances osteoclastogenesis, and may enhance established skeletal tumor burden by increasing osteoclasts activity |
| constitutional
|
|
| --over
|
|
|
with CXCL12 in patients with heart failure |
| constitutional
|
|
|
| gain of function
|
CXCR4 activation, by promoting the differentiation of oligodendrocyte precursor cells into oligodendrocytes, is critical for remyelination of the injured adult CNS  |
| tumoral
|
|
| --over
|
|
|
significantly associated with lymph node status and distant metastasis and indicated poor overall and disease free survival |
