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FLASH GENE
Symbol SLC3A1 contributors: mct/npt - updated : 21-10-2009
HGNC name solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
HGNC id 11025
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Endocrineneuroendocrinepituitary  highly
Urinarybladder    
 kidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Urinaryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six potential N-glycosylation sites which might be functional in the oocyte (Bertran 1993)
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 3, neutral aminoacid
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text colocated in the brush border of the plasma membrane
    basic FUNCTION
  • Na+ dependent dibasic (cystine,lysine),neutral aminoacid transport,high affinity
  • mediating high affinity y+L-type transporter exchanging cationic aminoacids and/or neutral aminoacids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with BO+AT (SLC3A1)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSNU1 , HCYS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS